Double and multiple knockout simulations for genome-scale metabolic network reconstructions.
Algorithms Mol Biol
; 10(1): 1, 2015.
Article
em En
| MEDLINE
| ID: mdl-25649004
ABSTRACT
BACKGROUND:
Constraint-based modeling of genome-scale metabolic network reconstructions has become a widely used approach in computational biology. Flux coupling analysis is a constraint-based method that analyses the impact of single reaction knockouts on other reactions in the network.RESULTS:
We present an extension of flux coupling analysis for double and multiple gene or reaction knockouts, and develop corresponding algorithms for an in silico simulation. To evaluate our method, we perform a full single and double knockout analysis on a selection of genome-scale metabolic network reconstructions and compare the results. SOFTWARE A prototype implementation of double knockout simulation is available at http//hoverboard.io/L4FC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Algorithms Mol Biol
Ano de publicação:
2015
Tipo de documento:
Article