Activation of GLP-1 receptors on vascular smooth muscle cells reduces the autoregulatory response in afferent arterioles and increases renal blood flow.

Jensen, Elisa P; Poulsen, Steen S; Kissow, Hannelouise; Holstein-Rathlou, Niels-Henrik; Deacon, Carolyn F; Jensen, Boye L; Holst, Jens J; Sorensen, Charlotte M

Jensen, Elisa P; Poulsen, Steen S; Kissow, Hannelouise; Holstein-Rathlou, Niels-Henrik; Deacon, Carolyn F; Jensen, Boye L; Holst, Jens J; Sorensen, Charlotte M.

Afiliação

Jensen EP; Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; NNF Center for Basic Metabolic Research, Panum Institute, University of Copenhagen, Copenhagen, Denmark; and.
Poulsen SS; Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; NNF Center for Basic Metabolic Research, Panum Institute, University of Copenhagen, Copenhagen, Denmark; and.
Kissow H; Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; NNF Center for Basic Metabolic Research, Panum Institute, University of Copenhagen, Copenhagen, Denmark; and.
Holstein-Rathlou NH; Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark;
Deacon CF; Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; NNF Center for Basic Metabolic Research, Panum Institute, University of Copenhagen, Copenhagen, Denmark; and.
Jensen BL; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Holst JJ; Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; NNF Center for Basic Metabolic Research, Panum Institute, University of Copenhagen, Copenhagen, Denmark; and.
Sorensen CM; Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; cmehlin@sund.ku.dk.

Am J Physiol Renal Physiol ; 308(8): F867-77, 2015 Apr 15.

Article em En | MEDLINE | ID: mdl-25656368

Assuntos

Peptídeo 1 Semelhante ao Glucagon/metabolismo; Rim/irrigação sanguínea; Músculo Liso Vascular/metabolismo; Miócitos de Músculo Liso/metabolismo; Receptores de Glucagon/metabolismo; Circulação Renal; Animais; Arteríolas/metabolismo; Autorradiografia; Pressão Sanguínea; Exenatida; Feminino; Receptor do Peptídeo Semelhante ao Glucagon 1; Frequência Cardíaca; Homeostase; Imuno-Histoquímica; Camundongos Endogâmicos C57BL; Microcirculação; Músculo Liso Vascular/efeitos dos fármacos; Miócitos de Músculo Liso/efeitos dos fármacos; Peptídeos/farmacologia; Potássio/sangue; Potássio/urina; Ratos Sprague-Dawley; Ratos Wistar; Receptores de Glucagon/agonistas; Circulação Renal/efeitos dos fármacos; Eliminação Renal; Renina/sangue; Transdução de Sinais; Sódio/sangue; Sódio/urina; Fatores de Tempo; Urodinâmica; Peçonhas/farmacologia

Palavras-chave

afferent arteriole; glucagon-like peptide-1; glucagon-like peptide-1 receptor; kidney; renal blood flow

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Circulação Renal / Receptores de Glucagon / Miócitos de Músculo Liso / Peptídeo 1 Semelhante ao Glucagon / Rim / Músculo Liso Vascular Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Am J Physiol Renal Physiol Assunto da revista: FISIOLOGIA / NEFROLOGIA Ano de publicação: 2015 Tipo de documento: Article

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