Loss of mitochondrial SDHB expression: what is its role in diffuse thyroid lipomatosis?
Horm Metab Res
; 47(3): 165-7, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25679879
Diffuse lipomatosis of the thyroid gland is a very rare disease, characterized by extensive infiltration of thyroid parenchyma by mature adipose tissue, usually not accompanied by amyloid fibrils deposition. The pathophysiology of adipose tissue infiltration in the thyroid gland remains unknown. We report a clinical case of a diffuse thyroid lipomatosis, whose immunohistochemical study of succinate dehydrogenase - subunit B (SDHB) revealed loss of expression of this protein in the follicular or adipose cells. We detected the presence of a recently described SDHB gene large deletion. Loss of mitochondrial SDHB expression may have a key role in understanding the pathophysiology of thyrolipomatosis, by regulating status of lipid metabolism.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Succinato Desidrogenase
/
Deleção de Genes
/
Hipotireoidismo
/
Lipomatose
/
Mitocôndrias
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Horm Metab Res
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Portugal