Inhibition of KIT-glycosylation by 2-deoxyglucose abrogates KIT-signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor.

Mühlenberg, Thomas; Grunewald, Susanne; Treckmann, Jürgen; Podleska, Lars; Schuler, Martin; Fletcher, Jonathan A; Bauer, Sebastian

Mühlenberg, Thomas; Grunewald, Susanne; Treckmann, Jürgen; Podleska, Lars; Schuler, Martin; Fletcher, Jonathan A; Bauer, Sebastian.

Afiliação

Mühlenberg T; Dept. of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Sarcoma Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Grunewald S; Dept. of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Sarcoma Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Treckmann J; Sarcoma Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Dept. of Visceral and Transplant Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germa
Podleska L; Sarcoma Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Dept. of Visceral and Transplant Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germa
Schuler M; Dept. of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany.
Fletcher JA; Dept. of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Bauer S; Dept. of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Sarcoma Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

PLoS One ; 10(3): e0120531, 2015.

Article em En | MEDLINE | ID: mdl-25781619

Assuntos

Compostos de Anilina/farmacologia; Apoptose/efeitos dos fármacos; Desoxiglucose/farmacologia; Tumores do Estroma Gastrointestinal/metabolismo; Proteínas Proto-Oncogênicas c-kit/metabolismo; Transdução de Sinais/efeitos dos fármacos; Sulfonamidas/farmacologia; Compostos de Anilina/agonistas; Animais; Apoptose/genética; Linhagem Celular Tumoral; Desoxiglucose/agonistas; Sinergismo Farmacológico; Tumores do Estroma Gastrointestinal/genética; Tumores do Estroma Gastrointestinal/patologia; Glicosilação/efeitos dos fármacos; Humanos; Camundongos; Camundongos Nus; Proteínas Proto-Oncogênicas c-kit/genética; Transdução de Sinais/genética; Sulfonamidas/agonistas

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Transdução de Sinais / Apoptose / Proteínas Proto-Oncogênicas c-kit / Tumores do Estroma Gastrointestinal / Desoxiglucose / Compostos de Anilina Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Alemanha

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