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Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer.
Marshall, Derek C; Lyman, Susan K; McCauley, Scott; Kovalenko, Maria; Spangler, Rhyannon; Liu, Chian; Lee, Michael; O'Sullivan, Christopher; Barry-Hamilton, Vivian; Ghermazien, Haben; Mikels-Vigdal, Amanda; Garcia, Carlos A; Jorgensen, Brett; Velayo, Arleene C; Wang, Ruth; Adamkewicz, Joanne I; Smith, Victoria.
Afiliação
  • Marshall DC; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • Lyman SK; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • McCauley S; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • Kovalenko M; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • Spangler R; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • Liu C; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • Lee M; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • O'Sullivan C; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • Barry-Hamilton V; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • Ghermazien H; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • Mikels-Vigdal A; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • Garcia CA; Department of Process Development, Gilead Sciences, Inc., Oceanside, California, United States of America.
  • Jorgensen B; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • Velayo AC; Department of Process Development, Gilead Sciences, Inc., Oceanside, California, United States of America.
  • Wang R; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • Adamkewicz JI; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
  • Smith V; Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America.
PLoS One ; 10(5): e0127063, 2015.
Article em En | MEDLINE | ID: mdl-25961845
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Colite Ulcerativa / Regulação Neoplásica da Expressão Gênica / Metaloproteinase 9 da Matriz / Anticorpos Monoclonais Humanizados / Inibidores de Metaloproteinases de Matriz / Antineoplásicos Tipo de estudo: Prognostic_studies Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Colite Ulcerativa / Regulação Neoplásica da Expressão Gênica / Metaloproteinase 9 da Matriz / Anticorpos Monoclonais Humanizados / Inibidores de Metaloproteinases de Matriz / Antineoplásicos Tipo de estudo: Prognostic_studies Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos