Aberrant glomerular filtration of urokinase-type plasminogen activator in nephrotic syndrome leads to amiloride-sensitive plasminogen activation in urine.

Stæhr, Mette; Buhl, Kristian B; Andersen, René F; Svenningsen, Per; Nielsen, Flemming; Hinrichs, Gitte Rye; Bistrup, Claus; Jensen, Boye L

Stæhr, Mette; Buhl, Kristian B; Andersen, René F; Svenningsen, Per; Nielsen, Flemming; Hinrichs, Gitte Rye; Bistrup, Claus; Jensen, Boye L.

Afiliação

Stæhr M; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark;
Buhl KB; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark;
Andersen RF; Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark;
Svenningsen P; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark;
Nielsen F; Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense, Denmark; and.
Hinrichs GR; Department of Nephrology, Odense University Hospital, Odense, Denmark.
Bistrup C; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Department of Nephrology, Odense University Hospital, Odense, Denmark.
Jensen BL; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; bljensen@health.sdu.dk.

Am J Physiol Renal Physiol ; 309(3): F235-41, 2015 Aug 01.

Article em En | MEDLINE | ID: mdl-25972510

Assuntos

Amilorida/farmacologia; Bloqueadores do Canal de Sódio Epitelial/farmacologia; Glomérulos Renais/metabolismo; Síndrome Nefrótica/metabolismo; Plasminogênio/urina; Ativador de Plasminogênio Tipo Uroquinase/metabolismo; Adulto; Animais; Criança; Canais Epiteliais de Sódio/metabolismo; Humanos; Masculino; Síndrome Nefrótica/induzido quimicamente; Puromicina Aminonucleosídeo; Ratos; Ratos Sprague-Dawley

Palavras-chave

ENaC; edema; proteinuria; proteolysis; sodium

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasminogênio / Ativador de Plasminogênio Tipo Uroquinase / Bloqueadores do Canal de Sódio Epitelial / Amilorida / Glomérulos Renais / Síndrome Nefrótica Tipo de estudo: Diagnostic_studies Limite: Adult / Animals / Child / Humans / Male Idioma: En Revista: Am J Physiol Renal Physiol Assunto da revista: FISIOLOGIA / NEFROLOGIA Ano de publicação: 2015 Tipo de documento: Article

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