Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City.
Antimicrob Agents Chemother
; 59(8): 5029-31, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26014931
ABSTRACT
Imipenem with relebactam was active against Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp., including K. pneumoniae carbapenemase (KPC)-producing isolates. Loss of OmpK36 in KPC-producing K. pneumoniae isolates affected the susceptibility of this combination. Enhanced activity was evident against Pseudomonas aeruginosa, including isolates with depressed oprD and increased ampC expression. However, the addition of relebactam to imipenem did not provide added benefit against Acinetobacter baumannii. The combination of imipenem with relebactam demonstrated activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
/
Imipenem
/
Acinetobacter baumannii
/
Enterobacteriaceae
/
Compostos Azabicíclicos
/
Inibidores de beta-Lactamases
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos