Systematic Screening of Promoter Regions Pinpoints Functional Cis-Regulatory Mutations in a Cutaneous Melanoma Genome.

Poulos, Rebecca C; Thoms, Julie A I; Shah, Anushi; Beck, Dominik; Pimanda, John E; Wong, Jason W H

Poulos, Rebecca C; Thoms, Julie A I; Shah, Anushi; Beck, Dominik; Pimanda, John E; Wong, Jason W H.

Afiliação

Poulos RC; Prince of Wales Clinical School, University of New South Wales Australia, Sydney, Australia. Lowy Cancer Research Centre, University of New South Wales Australia, Sydney, Australia.
Thoms JA; Prince of Wales Clinical School, University of New South Wales Australia, Sydney, Australia. Lowy Cancer Research Centre, University of New South Wales Australia, Sydney, Australia.
Shah A; Prince of Wales Clinical School, University of New South Wales Australia, Sydney, Australia. Lowy Cancer Research Centre, University of New South Wales Australia, Sydney, Australia.
Beck D; Prince of Wales Clinical School, University of New South Wales Australia, Sydney, Australia. Lowy Cancer Research Centre, University of New South Wales Australia, Sydney, Australia.
Pimanda JE; Prince of Wales Clinical School, University of New South Wales Australia, Sydney, Australia. Lowy Cancer Research Centre, University of New South Wales Australia, Sydney, Australia. Department of Haematology, Prince of Wales Hospital, Sydney, Australia.
Wong JW; Prince of Wales Clinical School, University of New South Wales Australia, Sydney, Australia. Lowy Cancer Research Centre, University of New South Wales Australia, Sydney, Australia. jason.wong@unsw.edu.au.

Mol Cancer Res ; 13(8): 1218-26, 2015 Aug.

Article em En | MEDLINE | ID: mdl-26082173

Assuntos

Melanoma/genética; Mutação; Regiões Promotoras Genéticas; Elementos Reguladores de Transcrição; Neoplasias Cutâneas/genética; Linhagem Celular Tumoral; Cromatina/metabolismo; Genes Reporter; Técnicas Genéticas; Genoma Humano; Humanos; Modelos Genéticos; NADH Desidrogenase/genética; Fator de Transcrição Sp1/metabolismo; Transcrição Gênica; Melanoma Maligno Cutâneo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Regiões Promotoras Genéticas / Elementos Reguladores de Transcrição / Melanoma / Mutação Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Humans Idioma: En Revista: Mol Cancer Res Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Austrália

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