The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain.
Curr Osteoporos Rep
; 13(5): 318-26, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26233284
ABSTRACT
Knee osteoarthritis is characterized by progressive damage and remodeling of all tissues in the knee joint. Pain is the main symptom associated with knee osteoarthritis. Recent clinical and pre-clinical studies have provided novel insights into the mechanisms that drive the pain associated with joint destruction. In this narrative review, we describe current knowledge regarding the changes in the peripheral and central nervous systems that occur during the progression of osteoarthritis and discuss how therapeutic interventions may provide pain relief.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nociceptores
/
Osteoartrite do Joelho
/
Dor Crônica
Limite:
Humans
Idioma:
En
Revista:
Curr Osteoporos Rep
Assunto da revista:
ORTOPEDIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos