Genetic engineering, high resolution mass spectrometry and nuclear magnetic resonance spectroscopy elucidate the bikaverin biosynthetic pathway in Fusarium fujikuroi.

Arndt, Birgit; Studt, Lena; Wiemann, Philipp; Osmanov, Helena; Kleigrewe, Karin; Köhler, Jens; Krug, Isabel; Tudzynski, Bettina; Humpf, Hans-Ulrich

Arndt, Birgit; Studt, Lena; Wiemann, Philipp; Osmanov, Helena; Kleigrewe, Karin; Köhler, Jens; Krug, Isabel; Tudzynski, Bettina; Humpf, Hans-Ulrich.

Afiliação

Arndt B; Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 45, 48149 Münster, Germany; NRW Graduate School of Chemistry, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Str. 10, 48149 Münster, Germany.
Studt L; Institute of Molecular Biology and Biotechnology of Fungi, Westfälische Wilhelms-Universität Münster, Schlossplatz 8, 48149 Münster, Germany.
Wiemann P; Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 45, 48149 Münster, Germany; Institute of Molecular Biology and Biotechnology of Fungi, Westfälische Wilhelms-Universität Münster, Schlossplatz 8, 48149 Münster, Germany.
Osmanov H; Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 45, 48149 Münster, Germany; Institute of Molecular Biology and Biotechnology of Fungi, Westfälische Wilhelms-Universität Münster, Schlossplatz 8, 48149 Münster, Germany.
Kleigrewe K; Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 45, 48149 Münster, Germany.
Köhler J; Institute of Pharmaceutical and Medicinal Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 48, 48149 Münster, Germany.
Krug I; Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 45, 48149 Münster, Germany.
Tudzynski B; Institute of Molecular Biology and Biotechnology of Fungi, Westfälische Wilhelms-Universität Münster, Schlossplatz 8, 48149 Münster, Germany.
Humpf HU; Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 45, 48149 Münster, Germany; NRW Graduate School of Chemistry, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Str. 10, 48149 Münster, Germany. Electronic address: humpf@wwu.de.

Fungal Genet Biol ; 84: 26-36, 2015 Nov.

Article em En | MEDLINE | ID: mdl-26382642

Assuntos

Fusarium/genética; Fusarium/metabolismo; Engenharia Genética/métodos; Espectroscopia de Ressonância Magnética/métodos; Espectrometria de Massas/métodos; Xantonas/metabolismo; Vias Biossintéticas; Proliferação de Células/efeitos dos fármacos; Proteínas Fúngicas/genética; Proteínas Fúngicas/metabolismo; Genes Fúngicos; Células Hep G2; Humanos; Família Multigênica; Mutação; Oryza/microbiologia; Xantonas/química; Xantonas/isolamento & purificação; Xantonas/farmacologia

Palavras-chave

Bikaverin; Biosynthesis; Fusarium; Genomics; Mass spectrometry; NMR spectroscopy; Natural products

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Espectroscopia de Ressonância Magnética / Engenharia Genética / Xantonas / Fusarium Limite: Humans Idioma: En Revista: Fungal Genet Biol Assunto da revista: GENETICA / MICROBIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Alemanha

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