Stem cell therapy for cardiac regeneration: hits and misses.
Can J Physiol Pharmacol
; 93(10): 835-41, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26443930
ABSTRACT
Cardiac injury and loss of cardiomyocytes is a causative as well as a resultant condition of cardiovascular disorders, which are the leading cause of death throughout the world. This loss of cardiomyocytes cannot be completely addressed through the currently available drugs being administered, which mainly function only in relieving the symptoms. There is a huge potential being investigated for regenerative and cell replacement therapies through recruiting stem cells of various origins namely embryonic, reprogramming/induction, and adult tissue. These sources are being actively studied for translation to clinical scenarios. In this review, we attempt to discuss some of these promising scenarios, including the clinical trials and the obstacles that need to be overcome, and hope to address the direction in which stem cell therapy is heading.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Medula Óssea
/
Miócitos Cardíacos
/
Transplante de Células-Tronco Mesenquimais
/
Reprogramação Celular
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Células-Tronco Pluripotentes Induzidas
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Cardiopatias
Limite:
Humans
Idioma:
En
Revista:
Can J Physiol Pharmacol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Canadá