The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-&#954;B signalling.

Klein, Theo; Fung, Shan-Yu; Renner, Florian; Blank, Michael A; Dufour, Antoine; Kang, Sohyeong; Bolger-Munro, Madison; Scurll, Joshua M; Priatel, John J; Schweigler, Patrick; Melkko, Samu; Gold, Michael R; Viner, Rosa I; Régnier, Catherine H; Turvey, Stuart E; Overall, Christopher M

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.

Klein, Theo; Fung, Shan-Yu; Renner, Florian; Blank, Michael A; Dufour, Antoine; Kang, Sohyeong; Bolger-Munro, Madison; Scurll, Joshua M; Priatel, John J; Schweigler, Patrick; Melkko, Samu; Gold, Michael R; Viner, Rosa I; Régnier, Catherine H; Turvey, Stuart E; Overall, Christopher M.

Afiliação

Klein T; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Fung SY; Department of Oral Biological and Medical Science, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Renner F; Center for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Blank MA; Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Dufour A; Child &Family Research Institute, BC Children's Hospital, Vancouver, British Columbia, Canada V6T 1Z3.
Kang S; Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland.
Bolger-Munro M; Thermo Fisher Scientific, 355 River Oaks Parkway, San Jose, 95134 California, USA.
Scurll JM; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Priatel JJ; Department of Oral Biological and Medical Science, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Schweigler P; Child &Family Research Institute, BC Children's Hospital, Vancouver, British Columbia, Canada V6T 1Z3.
Melkko S; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4.
Gold MR; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Viner RI; Department of Mathematics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Régnier CH; Child &Family Research Institute, BC Children's Hospital, Vancouver, British Columbia, Canada V6T 1Z3.
Turvey SE; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4.
Overall CM; Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland.

Nat Commun ; 6: 8777, 2015 Nov 03.

Article em En | MEDLINE | ID: mdl-26525107

Assuntos

Caspases/genética; Síndromes de Imunodeficiência/genética; Linfócitos/imunologia; NF-kappa B/metabolismo; Proteínas de Neoplasias/genética; Ubiquitina-Proteína Ligases/metabolismo; Adolescente; Adulto; Animais; Células Apresentadoras de Antígenos; Linfócitos B/imunologia; Caspases/imunologia; Caspases/metabolismo; Família; Feminino; Imunofluorescência; Proteínas Ativadoras de GTPase/metabolismo; Técnicas de Introdução de Genes; Humanos; Quinase I-kappa B/metabolismo; Immunoblotting; Síndromes de Imunodeficiência/imunologia; Imunoprecipitação; Técnicas In Vitro; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Leucócitos Mononucleares; Masculino; Espectrometria de Massas; Camundongos; Microscopia Confocal; Proteína de Translocação 1 do Linfoma de Tecido Linfoide Associado à Mucosa; Mutação; NF-kappa B/imunologia; Proteínas de Neoplasias/imunologia; Proteínas de Neoplasias/metabolismo; Complexo de Proteínas Formadoras de Poros Nucleares/metabolismo; Tonsila Palatina; Proteômica; Proteínas de Ligação a RNA/metabolismo; Linfócitos T/imunologia; Espectrometria de Massas em Tandem; Fatores de Transcrição; Ubiquitinação/imunologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos / NF-kappa B / Caspases / Ubiquitina-Proteína Ligases / Síndromes de Imunodeficiência / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2015 Tipo de documento: Article

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