Specific transport of 3-fluoro-l-&#945;-methyl-tyrosine by LAT1 explains its specificity to malignant tumors in imaging.

Wei, Ling; Tominaga, Hideyuki; Ohgaki, Ryuichi; Wiriyasermkul, Pattama; Hagiwara, Kohei; Okuda, Suguru; Kaira, Kyoichi; Oriuchi, Noboru; Nagamori, Shushi; Kanai, Yoshikatsu

Specific transport of 3-fluoro-l-α-methyl-tyrosine by LAT1 explains its specificity to malignant tumors in imaging.

Wei, Ling; Tominaga, Hideyuki; Ohgaki, Ryuichi; Wiriyasermkul, Pattama; Hagiwara, Kohei; Okuda, Suguru; Kaira, Kyoichi; Oriuchi, Noboru; Nagamori, Shushi; Kanai, Yoshikatsu.

Afiliação

Wei L; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan.
Tominaga H; Advanced Clinical Research Center, Fukushima Medical University, Fukushima, Japan.
Ohgaki R; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan.
Wiriyasermkul P; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan.
Hagiwara K; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan.
Okuda S; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan.
Kaira K; Department of Oncology Clinical Development, Gunma University Graduate School of Medicine, Maebashi, Japan.
Oriuchi N; Advanced Clinical Research Center, Fukushima Medical University, Fukushima, Japan.
Nagamori S; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan.
Kanai Y; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan.

Cancer Sci ; 107(3): 347-52, 2016 Mar.

Article em En | MEDLINE | ID: mdl-26749017

Assuntos

Biomarcadores Tumorais/metabolismo; Transportador 1 de Aminoácidos Neutros Grandes/fisiologia; Metiltirosinas/metabolismo; Compostos Radiofarmacêuticos/metabolismo; Animais; Transporte Biológico; Técnicas de Silenciamento de Genes; Células HeLa; Humanos; RNA Interferente Pequeno/genética; Xenopus laevis

Palavras-chave

Amino acid transporter; PET; biomarker; molecular probe; tumor imaging

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Compostos Radiofarmacêuticos / Transportador 1 de Aminoácidos Neutros Grandes / Metiltirosinas Limite: Animals / Humans Idioma: En Revista: Cancer Sci Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

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