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Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure-activity relationships for (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives.
Hayashi, Shigeo; Ohashi, Katsuyo; Mihara, Sachiko; Nakata, Eriko; Emoto, Chie; Ohta, Atsuko.
Afiliação
  • Hayashi S; Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Japan Inc., 5-2 Taketoyo, Aichi 470-2393, Japan. Electronic address: Shigeo_Hayashi@nifty.com.
  • Ohashi K; Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Japan Inc., 5-2 Taketoyo, Aichi 470-2393, Japan.
  • Mihara S; Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Japan Inc., 5-2 Taketoyo, Aichi 470-2393, Japan.
  • Nakata E; Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Japan Inc., 5-2 Taketoyo, Aichi 470-2393, Japan.
  • Emoto C; Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Japan Inc., 5-2 Taketoyo, Aichi 470-2393, Japan.
  • Ohta A; Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Japan Inc., 5-2 Taketoyo, Aichi 470-2393, Japan.
Eur J Med Chem ; 114: 345-64, 2016 May 23.
Article em En | MEDLINE | ID: mdl-27043173
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Receptores Opioides / Bibliotecas de Moléculas Pequenas / Descoberta de Drogas / Hidrocarbonetos Acíclicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Receptores Opioides / Bibliotecas de Moléculas Pequenas / Descoberta de Drogas / Hidrocarbonetos Acíclicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2016 Tipo de documento: Article