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Protective Effects of Lithium on Sumatriptan-Induced Memory Impairment in Mice.
Nikoui, Vahid; Javadi-Paydar, Mehrak; Salehi, Mahtab; Behestani, Selda; Dehpour, Ahmad-Reza.
Afiliação
  • Nikoui V; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Javadi-Paydar M; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Salehi M; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Behestani S; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Dehpour AR; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Acta Med Iran ; 54(4): 226-32, 2016 Apr.
Article em En | MEDLINE | ID: mdl-27309262
ABSTRACT
Lithium is a drug used for the treatment of bipolar disorder. It has several mechanisms of action, and recently it is shown that lithium can antagonize the 5-HT1B/1D serotonin receptors. Sumatriptan is a 5-HT1B/1D receptor agonist used for the treatment of cluster headaches and migraine which might cause memory impairment as a potential side effect. In this study, effects of lithium on sumatriptan-induced memory impairment have been determined in a two-trial recognition Y-maze and passive avoidance tests. Male mice weighing 25-30 g were divided into several groups randomly. In Y-maze test, effects of lithium (1,5,10,20,40,80 mg/kg) and sumatriptan (1,5,10 mg/kg) were assessed on memory acquisition, then lithium (0.1,1,10 mg/kg) and sumatriptan (1,10 mg/kg) were studied in passive avoidance test. Effects of lithium (1mg/kg) on sumatriptan (10 mg/kg)-induced memory impairment were studied in both of tests. The present study demonstrated that sumatriptan impaired memory in Y-maze and passive avoidance tests (P<0.05, P<0.01, respectively). Lithium did not show any significant effect on memory function compared to saline-treated control group in both tests (P>0.05), but significantly reversed sumatriptan-induced memory impairment in Y-maze and passive avoidance tests (P<0.001, P<0.05, respectively). It is concluded that lithium reverses the sumatriptan-induced memory impairment probably through 5-HT1B/1D receptors antagonism.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sumatriptana / Lítio / Memória / Transtornos da Memória Limite: Animals Idioma: En Revista: Acta Med Iran Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Irã
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sumatriptana / Lítio / Memória / Transtornos da Memória Limite: Animals Idioma: En Revista: Acta Med Iran Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Irã