Increased plasmid copy number is essential for Yersinia T3SS function and virulence.
Science
; 353(6298): 492-5, 2016 Jul 29.
Article
em En
| MEDLINE
| ID: mdl-27365311
ABSTRACT
Pathogenic bacteria have evolved numerous virulence mechanisms that are essential for establishing infections. The enterobacterium Yersinia uses a type III secretion system (T3SS) encoded by a 70-kilobase, low-copy, IncFII-class virulence plasmid. We report a novel virulence strategy in Y. pseudotuberculosis in which this pathogen up-regulates the plasmid copy number during infection. We found that an increased dose of plasmid-encoded genes is indispensable for virulence and substantially elevates the expression and function of the T3SS. Remarkably, we observed direct, tight coupling between plasmid replication and T3SS function. This regulatory pathway provides a framework for further exploration of the environmental sensing mechanisms of pathogenic bacteria.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmídeos
/
Yersinia pseudotuberculosis
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Infecções por Yersinia pseudotuberculosis
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Regulação Bacteriana da Expressão Gênica
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Fatores de Virulência
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Sistemas de Secreção Tipo III
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Suécia