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Systematic chemical modifications of single stranded siRNAs significantly improved CTNNB1 mRNA silencing.
Chang, Wonsuk; Pei, Yi; Guidry, Erin N; Zewge, Daniel; Parish, Craig A; Sherer, Edward C; DiMuzio, Jillian; Zhang, Hangchun; South, Victoria J; Strapps, Walter R; Sepp-Lorenzino, Laura; Colletti, Steven L; Stanton, Matthew G.
Afiliação
  • Chang W; Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States. Electronic address: wonsuk.chang@merck.com.
  • Pei Y; RNA Biology, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, United States.
  • Guidry EN; Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Zewge D; Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, United States.
  • Parish CA; Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, United States.
  • Sherer EC; Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, United States.
  • DiMuzio J; RNA Biology, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, United States.
  • Zhang H; RNA Biology, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, United States.
  • South VJ; RNA Biology, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, United States.
  • Strapps WR; RNA Biology, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, United States.
  • Sepp-Lorenzino L; RNA Biology, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, United States.
  • Colletti SL; Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States.
  • Stanton MG; Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, United States.
Bioorg Med Chem Lett ; 26(18): 4513-4517, 2016 09 15.
Article em En | MEDLINE | ID: mdl-27503684
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Inativação Gênica / RNA Interferente Pequeno / Beta Catenina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Inativação Gênica / RNA Interferente Pequeno / Beta Catenina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article