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Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
Kato, Nobutaka; Comer, Eamon; Sakata-Kato, Tomoyo; Sharma, Arvind; Sharma, Manmohan; Maetani, Micah; Bastien, Jessica; Brancucci, Nicolas M; Bittker, Joshua A; Corey, Victoria; Clarke, David; Derbyshire, Emily R; Dornan, Gillian L; Duffy, Sandra; Eckley, Sean; Itoe, Maurice A; Koolen, Karin M J; Lewis, Timothy A; Lui, Ping S; Lukens, Amanda K; Lund, Emily; March, Sandra; Meibalan, Elamaran; Meier, Bennett C; McPhail, Jacob A; Mitasev, Branko; Moss, Eli L; Sayes, Morgane; Van Gessel, Yvonne; Wawer, Mathias J; Yoshinaga, Takashi; Zeeman, Anne-Marie; Avery, Vicky M; Bhatia, Sangeeta N; Burke, John E; Catteruccia, Flaminia; Clardy, Jon C; Clemons, Paul A; Dechering, Koen J; Duvall, Jeremy R; Foley, Michael A; Gusovsky, Fabian; Kocken, Clemens H M; Marti, Matthias; Morningstar, Marshall L; Munoz, Benito; Neafsey, Daniel E; Sharma, Amit; Winzeler, Elizabeth A; Wirth, Dyann F.
Afiliação
  • Kato N; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Comer E; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Sakata-Kato T; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA.
  • Sharma A; Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India.
  • Sharma M; Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India.
  • Maetani M; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Bastien J; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
  • Brancucci NM; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Bittker JA; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA.
  • Corey V; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Clarke D; School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, California 92093, USA.
  • Derbyshire ER; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA.
  • Dornan GL; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Duffy S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.
  • Eckley S; Department of Chemistry and Department of Molecular Genetics and Microbiology, Duke University, 124 Science Drive, Durham, North Carolina 27708, USA.
  • Itoe MA; Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria, British Colombia V8P 5C2, Canada.
  • Koolen KM; Eskitis Institute for Drug Discovery, Griffith University, Nathan Campus, Griffith University, Nathan, Brisbane, Queensland 4111, Australia.
  • Lewis TA; Eisai Inc., 4 Corporate Drive, Andover, Massachusetts 01810, USA.
  • Lui PS; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA.
  • Lukens AK; TropIQ Health Sciences, Geert Grooteplein 28, Huispost 268, 6525 GA Nijmegen, The Netherlands.
  • Lund E; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • March S; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA.
  • Meibalan E; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Meier BC; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA.
  • McPhail JA; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA.
  • Mitasev B; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Moss EL; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, USA.
  • Sayes M; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA.
  • Van Gessel Y; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Wawer MJ; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
  • Yoshinaga T; Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria, British Colombia V8P 5C2, Canada.
  • Zeeman AM; Eisai Inc., 4 Corporate Drive, Andover, Massachusetts 01810, USA.
  • Avery VM; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Bhatia SN; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Burke JE; Eisai Inc., 4 Corporate Drive, Andover, Massachusetts 01810, USA.
  • Catteruccia F; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Clardy JC; Eisai Co. Ltd, 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan.
  • Clemons PA; Department of Parasitology, Biochemical Primate Research Centre, 2280 GH Rijswijk, The Netherlands.
  • Dechering KJ; Eskitis Institute for Drug Discovery, Griffith University, Nathan Campus, Griffith University, Nathan, Brisbane, Queensland 4111, Australia.
  • Duvall JR; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Foley MA; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, USA.
  • Gusovsky F; Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria, British Colombia V8P 5C2, Canada.
  • Kocken CH; Harvard T.H. Chan School of Public Health, 665 Huntington Avenue Boston, Massachusetts 02115, USA.
  • Marti M; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Morningstar ML; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.
  • Munoz B; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Neafsey DE; TropIQ Health Sciences, Geert Grooteplein 28, Huispost 268, 6525 GA Nijmegen, The Netherlands.
  • Sharma A; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Winzeler EA; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
  • Wirth DF; Eisai Inc., 4 Corporate Drive, Andover, Massachusetts 01810, USA.
Nature ; 538(7625): 344-349, 2016 Oct 20.
Article em En | MEDLINE | ID: mdl-27602946
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Azetidinas / Malária Falciparum / Descoberta de Drogas / Estágios do Ciclo de Vida / Antimaláricos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Azetidinas / Malária Falciparum / Descoberta de Drogas / Estágios do Ciclo de Vida / Antimaláricos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos