Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice.

Gankhuyag, Nomundelger; Yu, Kyeong Nam; Davaadamdin, Orkhonselenge; Lee, Somin; Cho, Won Young; Park, Changhoon; Jiang, Hu-Lin; Singh, Bijay; Chae, Chan-Hee; Cho, Myung-Haing; Cho, Chong-Su

Gankhuyag, Nomundelger; Yu, Kyeong Nam; Davaadamdin, Orkhonselenge; Lee, Somin; Cho, Won Young; Park, Changhoon; Jiang, Hu-Lin; Singh, Bijay; Chae, Chan-Hee; Cho, Myung-Haing; Cho, Chong-Su.

Afiliação

Gankhuyag N; 1 Laboratory of Toxicology, BK21 PLUS Program for Creative Veterinary Science Research and The Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University , Seoul 151-742, Republic of Korea.
Yu KN; 1 Laboratory of Toxicology, BK21 PLUS Program for Creative Veterinary Science Research and The Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University , Seoul 151-742, Republic of Korea.
Davaadamdin O; 1 Laboratory of Toxicology, BK21 PLUS Program for Creative Veterinary Science Research and The Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University , Seoul 151-742, Republic of Korea.
Lee S; 1 Laboratory of Toxicology, BK21 PLUS Program for Creative Veterinary Science Research and The Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University , Seoul 151-742, Republic of Korea.
Cho WY; 1 Laboratory of Toxicology, BK21 PLUS Program for Creative Veterinary Science Research and The Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University , Seoul 151-742, Republic of Korea.
Park C; 2 Laboratory of Pathology, College of Veterinary Medicine, Seoul National University , Seoul, Korea.
Jiang HL; 3 State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University , Nanjing, China .
Singh B; 4 Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, Seoul National University , Seoul, Korea.
Chae CH; 2 Laboratory of Pathology, College of Veterinary Medicine, Seoul National University , Seoul, Korea.
Cho MH; 1 Laboratory of Toxicology, BK21 PLUS Program for Creative Veterinary Science Research and The Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University , Seoul 151-742, Republic of Korea.
Cho CS; 4 Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, Seoul National University , Seoul, Korea.

J Aerosol Med Pulm Drug Deliv ; 30(2): 81-90, 2017 Apr.

Article em En | MEDLINE | ID: mdl-27792477

Assuntos

Neoplasias Pulmonares/prevenção & controle; Proteínas/genética; RNA Interferente Pequeno/administração & dosagem; Espermina/administração & dosagem; Administração por Inalação; Aerossóis; Animais; Apoptose/genética; Carcinogênese/genética; Carcinógenos/toxicidade; Feminino; Glicerol/química; Marcação In Situ das Extremidades Cortadas; Neoplasias Pulmonares/etiologia; Neoplasias Pulmonares/genética; Camundongos; Nitrosaminas/toxicidade; Proteínas Proto-Oncogênicas c-bcl-2/genética; RNA Interferente Pequeno/genética; Nicotiana/toxicidade; Proteína X Associada a bcl-2/genética

Palavras-chave

A/J mice; NNK; aerosol-delivered shRab25; gene therapy; lung cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Espermina / RNA Interferente Pequeno / Neoplasias Pulmonares Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: J Aerosol Med Pulm Drug Deliv Assunto da revista: TERAPIA POR MEDICAMENTOS Ano de publicação: 2017 Tipo de documento: Article

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