Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic Opportunities.
Trends Biochem Sci
; 42(3): 206-218, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-27816326
ABSTRACT
Alkylation chemotherapy is one of the most widely used systemic therapies for cancer. While somewhat effective, clinical responses and toxicities of these agents are highly variable. A major contributing factor for this variability is the numerous distinct lesions that are created upon alkylation damage. These adducts activate multiple repair pathways. There is mounting evidence that the individual pathways function cooperatively, suggesting that coordinated regulation of alkylation repair is critical to prevent toxicity. Furthermore, some alkylating agents produce adducts that overlap with newly discovered methylation marks, making it difficult to distinguish between bona fide damaged bases and so-called 'epigenetic' adducts. Here, we discuss new efforts aimed at deciphering the mechanisms that regulate these repair pathways, emphasizing their implications for cancer chemotherapy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
DNA de Neoplasias
/
Reparo do DNA
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos