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Cell-based therapies for experimental diabetic nephropathy: a systematic review and meta-analysis.
Tang, H J; Tian, Z G; Yang, X; Cao, Y; Li, W G.
Afiliação
  • Tang HJ; School of Software, Beijing Institute of Technology, Beijing, China.
  • Tian ZG; Beijing Guangdalongtai Polytron Technologies Inc., Beijing, China.
  • Yang X; School of Software, Beijing Institute of Technology, Beijing, China.
  • Cao Y; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.
  • Li WG; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.
J Biol Regul Homeost Agents ; 30(4): 1047-1051, 2016.
Article em En | MEDLINE | ID: mdl-28078852
ABSTRACT
Study has shown that stem cell–based therapies are promising strategies in the treatment of several chronic diseases, but their overall benefit in the treatment of diabetic nephropathy (DN) remains controversial. The purpose of this study is to summarize the evidence of the effect of cell-based therapy in the treatment of DN to guide future clinical trials. We searched PubMed, EmBase, and the Cochrane Library for studies from the inception of cell-based therapies up to July 2015. We included animal trials that reported the effects of cell-based therapy on kidney function, cardiovascular risk factors, and body factors. A random-effects model was used to process the data, and the standard mean difference (SMD) was used to evaluate the efficacy of cell-based therapy. We included eight studies that reported data on 159 mice. Overall, we noted that cell-based therapies were associated with significantly reduced plasma creatinine level (P = 0.003), glomerular filtration rate (P less than 0.001), plasma glucose level (P = 0.004), serum cholesterol level (P = 0.010), serum triglyceride level (P = 0.032), plasma urea level (P less than 0.001), proteinuria (P = 0.008), and Cl- fractional excretion (P = 0.023). Furthermore, cell-based therapies were associated with lower kidney weight (P = 0.003), and kidney/body weight (P = 0.004). A sensitivity analysis suggested that cell-based therapy might play an important role in increased body weight. In conclusion, cell-based therapies significantly improve kidney function, cardiovascular risk factors, and body factors in the treatment of DN.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco / Nefropatias Diabéticas Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Animals Idioma: En Revista: J Biol Regul Homeost Agents Assunto da revista: BIOLOGIA / BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco / Nefropatias Diabéticas Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Animals Idioma: En Revista: J Biol Regul Homeost Agents Assunto da revista: BIOLOGIA / BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China