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Impact of Viral Respiratory Pathogens on Outcomes After Pediatric Cardiac Surgery.
Moynihan, Katie; Barlow, Andrew; Alphonso, Nelson; Anderson, Ben; Johnson, Janelle; Nourse, Clare; Schlebusch, Sanmarié; Karl, Tom R; Schlapbach, Luregn J.
Afiliação
  • Moynihan K; 1Paediatric Intensive Care Unit, Lady Cilento Children's Hospital, Brisbane, Australia. 2Paediatric Critical Care Research Group, Mater Research, University of Queensland, Brisbane, Australia. 3University of Queensland, Brisbane, Australia. 4Queensland Paediatric Cardiac Service, Lady Cilento Children's Hospital, Brisbane, Australia. 5Infection Management and Prevention Service, Lady Cilento Children's Hospital, Brisbane, Australia. 6Mater Pathology, Mater Misericordiae Ltd, Brisbane, Australia.
Pediatr Crit Care Med ; 18(3): 219-227, 2017 Mar.
Article em En | MEDLINE | ID: mdl-28114162
ABSTRACT

OBJECTIVES:

Viral respiratory infection is commonly considered a relative contraindication to elective cardiac surgery. We aimed to determine the frequency and outcomes of symptomatic viral respiratory infection in pediatric cardiac surgical patients.

DESIGN:

Retrospective cohort study of children undergoing cardiac surgery. Symptomatic children were tested using a multiplex Polymerase Chain Reaction (respiratory virus polymerase chain reaction) panel capturing nine respiratory viruses. Tests performed between 72 prior to and 48 hours after PICU admission were included. Mortality, length of stay in PICU, and intubation duration were investigated as outcomes.

SETTING:

Tertiary PICU providing state-wide pediatric cardiac services. PATIENTS Children less than 18 years admitted January 1, 2008 to November 29, 2014 for cardiac surgery. MEASUREMENTS AND MAIN

RESULTS:

Respiratory virus polymerase chain reaction was positive in 73 (4.2%) of 1,737 pediatric cardiac surgical admissions, including 13 children with multiple viruses detected. Commonly detected viruses included rhino/enterovirus (48%), adenovirus (32%), parainfluenza virus 3 (10%), and respiratory syncytial virus (3%). Pediatric Index of Mortality 2, Aristotle scores, and cardiopulmonary bypass times were similar between virus positive and negative/untested cohorts. Respiratory virus polymerase chain reaction positive patients had a median 2.0 days greater PICU length of stay (p < 0.001) and longer intubation duration (p < 0.001). Multivariate analysis adjusting for age, Aristotle score, cardiopulmonary bypass duration, and need for preoperative PICU admission confirmed that virus positive patients had significantly greater intubation duration and PICU length of stay (p < 0.001). Virus positive patients were more likely to require PICU admission greater than 4 days (odds ratio, 3.5; 95% CI, 1.9-6.2) and more likely to require intubation greater than 48 hours (odds ratio, 2.5; 95% CI, 1.4-4.7). There was no difference in mortality. No association was found between coinfection and outcomes.

CONCLUSIONS:

Pediatric cardiac surgical patients with a respiratory virus detected at PICU admission had prolonged postoperative recovery with increased length of stay and duration of intubation. Our results suggest that postponing cardiac surgery in children with symptomatic viral respiratory infection is appropriate, unless the benefits of early surgery outweigh the risk of prolonged ventilation and PICU stay.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / Viroses / Cardiopatias Congênitas / Procedimentos Cirúrgicos Cardíacos Tipo de estudo: Diagnostic_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Pediatr Crit Care Med Assunto da revista: PEDIATRIA / TERAPIA INTENSIVA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / Viroses / Cardiopatias Congênitas / Procedimentos Cirúrgicos Cardíacos Tipo de estudo: Diagnostic_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Pediatr Crit Care Med Assunto da revista: PEDIATRIA / TERAPIA INTENSIVA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Austrália