Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, <i>Amblyomma variegatum</i>.

Iyer, Janaki Krishnamoorthy; Koh, Cho Yeow; Kazimirova, Maria; Roller, Ladislav; Jobichen, Chacko; Swaminathan, Kunchithapadam; Mizuguchi, Jun; Iwanaga, Sadaaki; Nuttall, Patricia A; Chan, Mark Y; Kini, R Manjunatha

Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum.

Iyer, Janaki Krishnamoorthy; Koh, Cho Yeow; Kazimirova, Maria; Roller, Ladislav; Jobichen, Chacko; Swaminathan, Kunchithapadam; Mizuguchi, Jun; Iwanaga, Sadaaki; Nuttall, Patricia A; Chan, Mark Y; Kini, R Manjunatha.

Afiliação

Iyer JK; Protein Science Laboratory, Department of Biological Sciences, National University of Singapore, Singapore.
Koh CY; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Kazimirova M; Protein Science Laboratory, Department of Biological Sciences, National University of Singapore, Singapore.
Roller L; Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia.
Jobichen C; Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia.
Swaminathan K; Protein Science Laboratory, Department of Biological Sciences, National University of Singapore, Singapore.
Mizuguchi J; Protein Science Laboratory, Department of Biological Sciences, National University of Singapore, Singapore.
Iwanaga S; The Chemo-Sero-Therapeutic Research Institute, Kumamoto, Japan.
Nuttall PA; The Chemo-Sero-Therapeutic Research Institute, Kumamoto, Japan.
Chan MY; Department of Zoology, University of Oxford, Oxford, United Kingdom.
Kini RM; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

FASEB J ; 31(7): 2981-2995, 2017 07.

Article em En | MEDLINE | ID: mdl-28363953

Assuntos

Ixodidae/metabolismo; Peptídeos/farmacologia; Glândulas Salivares/metabolismo; Trombina/antagonistas & inibidores; Sequência de Aminoácidos; Animais; Proteínas de Artrópodes; Trombose das Artérias Carótidas/induzido quimicamente; Trombose das Artérias Carótidas/tratamento farmacológico; Bovinos; Cloretos/toxicidade; Clonagem Molecular; Feminino; Compostos Férricos/toxicidade; Fibrinogênio/metabolismo; Humanos; Calicreínas/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Ninfa; Glândulas Salivares/química; Tripsina/metabolismo

Palavras-chave

blood-feeding arthropods; blood-sucking animals; direct thrombin inhibitor; exosite-I inhibitor; thrombin-inhibitor complex

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Glândulas Salivares / Trombina / Ixodidae Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Singapura

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