Evaluation of dosing strategy for pembrolizumab for oncology indications.

Freshwater, Tomoko; Kondic, Anna; Ahamadi, Malidi; Li, Claire H; de Greef, Rik; de Alwis, Dinesh; Stone, Julie A

Freshwater, Tomoko; Kondic, Anna; Ahamadi, Malidi; Li, Claire H; de Greef, Rik; de Alwis, Dinesh; Stone, Julie A.

Afiliação

Freshwater T; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ USA.
Kondic A; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ USA.
Ahamadi M; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ USA.
Li CH; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ USA.
de Greef R; Quantitative Solutions, a Certara Company, Kloosterstraat 9, Oss, The Netherlands.
de Alwis D; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ USA.
Stone JA; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ USA.

J Immunother Cancer ; 5: 43, 2017.

Article em En | MEDLINE | ID: mdl-28515943

Assuntos

Anticorpos Monoclonais Humanizados/administração & dosagem; Antineoplásicos Imunológicos/administração & dosagem; Neoplasias/tratamento farmacológico; Anticorpos Monoclonais Humanizados/sangue; Anticorpos Monoclonais Humanizados/uso terapêutico; Antineoplásicos Imunológicos/sangue; Antineoplásicos Imunológicos/uso terapêutico; Peso Corporal; Relação Dose-Resposta a Droga; Humanos; Infusões Intravenosas; Modelos Biológicos; Neoplasias/sangue

Palavras-chave

Clinical dose; Dosing strategy; Exposure-response analysis; Fixed dose; Flat dose; Pembrolizumab; Population pharmacokinetics analysis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais Humanizados / Antineoplásicos Imunológicos / Neoplasias Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: J Immunother Cancer Ano de publicação: 2017 Tipo de documento: Article

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