Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease.

Iulita, M Florencia; Bistué Millón, M Beatriz; Pentz, Rowan; Aguilar, Lisi Flores; Do Carmo, Sonia; Allard, Simon; Michalski, Bernadeta; Wilson, Edward N; Ducatenzeiler, Adriana; Bruno, Martin A; Fahnestock, Margaret; Cuello, A Claudio

Iulita, M Florencia; Bistué Millón, M Beatriz; Pentz, Rowan; Aguilar, Lisi Flores; Do Carmo, Sonia; Allard, Simon; Michalski, Bernadeta; Wilson, Edward N; Ducatenzeiler, Adriana; Bruno, Martin A; Fahnestock, Margaret; Cuello, A Claudio.

Afiliação

Iulita MF; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
Bistué Millón MB; Facultad de Ciencias Médicas, Universidad Católica de Cuyo-CONICET, San Juan, Argentina.
Pentz R; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Aguilar LF; Department of Anatomy and Cell Biology, McGill University, Montreal, Canada.
Do Carmo S; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
Allard S; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
Michalski B; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.
Wilson EN; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Ducatenzeiler A; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
Bruno MA; Facultad de Ciencias Médicas, Universidad Católica de Cuyo-CONICET, San Juan, Argentina.
Fahnestock M; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.
Cuello AC; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada; Department of Anatomy and Cell Biology, McGill University, Montreal, Canada. Electronic address: claudio.cuello@mcgill.ca.

Neurobiol Dis ; 108: 307-323, 2017 Dec.

Article em En | MEDLINE | ID: mdl-28865749

Assuntos

Doença de Alzheimer/metabolismo; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Encéfalo/metabolismo; Fator de Crescimento Neural/metabolismo; Envelhecimento/metabolismo; Envelhecimento/patologia; Doença de Alzheimer/patologia; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Animais; Western Blotting; Encéfalo/patologia; Modelos Animais de Doenças; Progressão da Doença; Feminino; Regulação da Expressão Gênica; Humanos; Imuno-Histoquímica; Masculino; Metaloproteinase 9 da Matriz/metabolismo; Neurônios/metabolismo; Neurônios/patologia; Placa Amiloide/metabolismo; Placa Amiloide/patologia; RNA Mensageiro/metabolismo; Ratos Transgênicos

Palavras-chave

Alzheimer's disease; Amyloid-ß; BDNF; Cholinergic; MMP-9; Nerve growth factor; Neuroserpin; Neurotrophins; Synaptic plasticity; proNGF; tPA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Fator Neurotrófico Derivado do Encéfalo / Fator de Crescimento Neural / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Canadá

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