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Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs.
Ghavami, Maryam; Merino, Emilio F; Yao, Zhong-Ke; Elahi, Rubayet; Simpson, Morgan E; Fernández-Murga, Maria L; Butler, Joshua H; Casasanta, Michael A; Krai, Priscilla M; Totrov, Maxim M; Slade, Daniel J; Carlier, Paul R; Cassera, Maria Belen.
Afiliação
  • Ghavami M; Department of Chemistry and Virginia Tech Center for Drug Discovery , Virginia Tech , Hahn Hall South, 800 West Campus Drive , Blacksburg , Virginia 24061 , United States.
  • Merino EF; Department of Biochemistry and Virginia Tech Center for Drug Discovery , Virginia Tech , Engel Hall, 340 West Campus Drive , Blacksburg , Virginia 24061 , United States.
  • Yao ZK; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases (CTEGD) , University of Georgia , 120 Green Street , Athens , Georgia 30602 , United States.
  • Elahi R; Department of Chemistry and Virginia Tech Center for Drug Discovery , Virginia Tech , Hahn Hall South, 800 West Campus Drive , Blacksburg , Virginia 24061 , United States.
  • Simpson ME; Department of Biochemistry and Virginia Tech Center for Drug Discovery , Virginia Tech , Engel Hall, 340 West Campus Drive , Blacksburg , Virginia 24061 , United States.
  • Fernández-Murga ML; Department of Biochemistry and Virginia Tech Center for Drug Discovery , Virginia Tech , Engel Hall, 340 West Campus Drive , Blacksburg , Virginia 24061 , United States.
  • Butler JH; Department of Biochemistry and Virginia Tech Center for Drug Discovery , Virginia Tech , Engel Hall, 340 West Campus Drive , Blacksburg , Virginia 24061 , United States.
  • Casasanta MA; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases (CTEGD) , University of Georgia , 120 Green Street , Athens , Georgia 30602 , United States.
  • Krai PM; Department of Biochemistry and Virginia Tech Center for Drug Discovery , Virginia Tech , Engel Hall, 340 West Campus Drive , Blacksburg , Virginia 24061 , United States.
  • Totrov MM; Department of Biochemistry and Virginia Tech Center for Drug Discovery , Virginia Tech , Engel Hall, 340 West Campus Drive , Blacksburg , Virginia 24061 , United States.
  • Slade DJ; Molsoft LLC , 11199 Sorrento Valley Road , San Diego , California 92121 , United States.
  • Carlier PR; Department of Biochemistry and Virginia Tech Center for Drug Discovery , Virginia Tech , Engel Hall, 340 West Campus Drive , Blacksburg , Virginia 24061 , United States.
  • Cassera MB; Department of Chemistry and Virginia Tech Center for Drug Discovery , Virginia Tech , Hahn Hall South, 800 West Campus Drive , Blacksburg , Virginia 24061 , United States.
ACS Infect Dis ; 4(4): 549-559, 2018 04 13.
Article em En | MEDLINE | ID: mdl-29072835
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Pipecólicos / Plasmodium / Carbolinas / Inibidores Enzimáticos / Antimaláricos / Nucleotidiltransferases Idioma: En Revista: ACS Infect Dis Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Pipecólicos / Plasmodium / Carbolinas / Inibidores Enzimáticos / Antimaláricos / Nucleotidiltransferases Idioma: En Revista: ACS Infect Dis Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos