Novel and effective synthesis protocol of AgNPs functionalized using L-cysteine as a potential drug carrier.
Naunyn Schmiedebergs Arch Pharmacol
; 391(2): 123-130, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-29147738
ABSTRACT
In this study, the protocol of a single-step L-cysteine functionalized silver nanoparticle synthesis was described. Particle size distribution was determined. The crystallinity and chemical properties were investigated using XRD, HR-TEM, and XPS methods. Acute toxicity and irritant properties of obtained nanoparticles were studied using mice and rats as an animal model. The results showed that thanks to the applied protocol, it was possible to synthesize silver nanoparticles with narrow particle size distribution. Moreover, the concentration of final product was extremely high in comparison to other known methods. These nanoparticles showed neither irritant properties nor acute toxicity.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prata
/
Portadores de Fármacos
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Cisteína
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Nanopartículas Metálicas
Limite:
Animals
Idioma:
En
Revista:
Naunyn Schmiedebergs Arch Pharmacol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Polônia