Application of single nucleotide extension and MALDI-TOF mass spectrometry in proofreading and DNA repair assay.

Su, Kang-Yi; Lai, Hung-Ming; Goodman, Steven D; Hu, Wei-Yao; Cheng, Wern-Cherng; Lin, Liang-In; Yang, Ya-Chien; Fang, Woei-Horng

Su, Kang-Yi; Lai, Hung-Ming; Goodman, Steven D; Hu, Wei-Yao; Cheng, Wern-Cherng; Lin, Liang-In; Yang, Ya-Chien; Fang, Woei-Horng.

Afiliação

Su KY; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10002, Taiwan, ROC; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, 100-63, Taiwan, ROC.
Lai HM; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10002, Taiwan, ROC.
Goodman SD; Center for Microbial Pathogenesis, Nationwide Children's Hospital and The Department of Pediatrics, The Ohio State University, Columbus, OH, USA.
Hu WY; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10002, Taiwan, ROC.
Cheng WC; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, 100-63, Taiwan, ROC.
Lin LI; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10002, Taiwan, ROC; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, 100-63, Taiwan, ROC.
Yang YC; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10002, Taiwan, ROC; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, 100-63, Taiwan, ROC.
Fang WH; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10002, Taiwan, ROC; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, 100-63, Taiwan, ROC. Electronic address: whfang@ntu.edu.tw.

DNA Repair (Amst) ; 61: 63-75, 2018 01.

Article em En | MEDLINE | ID: mdl-29223016

Assuntos

Reparo do DNA; Replicação do DNA; Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz; DNA Polimerase I/metabolismo; Moldes Genéticos

Palavras-chave

3' Penultimate site; 3'-5' Exonuclease; DNA mismatch; DNA polymerase I; DNA repair; Deamination; Deoxyinosine; Endonuclease V; Enzyme activity; Escherichia coli proteins; Genetic stability; Heteroduplex; Internal mismatch; Klenow fragment; MALDI-TOF; Mass spectrometry; Polydeoxyribonucleotide synthase; Proofreading; Replication error; Substrate specificity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz / Reparo do DNA / Replicação do DNA Tipo de estudo: Prognostic_studies Idioma: En Revista: DNA Repair (Amst) Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article

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