Lytic viral replication and immunopathology in a cytomegalovirus-induced mouse model of secondary hemophagocytic lymphohistiocytosis.

Brisse, Ellen; Imbrechts, Maya; Mitera, Tania; Vandenhaute, Jessica; Wouters, Carine H; Snoeck, Robert; Andrei, Graciela; Matthys, Patrick

Brisse, Ellen; Imbrechts, Maya; Mitera, Tania; Vandenhaute, Jessica; Wouters, Carine H; Snoeck, Robert; Andrei, Graciela; Matthys, Patrick.

Afiliação

Brisse E; Laboratory of Immunobiology, Rega Institute, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Imbrechts M; Laboratory of Immunobiology, Rega Institute, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Mitera T; Laboratory of Immunobiology, Rega Institute, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Vandenhaute J; Laboratory of Immunobiology, Rega Institute, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Wouters CH; Laboratory of Pediatric Immunology, Department of Microbiology and Immunology, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium.
Snoeck R; Laboratory of Virology and Chemotherapy, Rega Institute, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Andrei G; Laboratory of Virology and Chemotherapy, Rega Institute, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Matthys P; Laboratory of Immunobiology, Rega Institute, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium. patrick.matthys@kuleuven.be.

Virol J ; 14(1): 240, 2017 12 19.

Article em En | MEDLINE | ID: mdl-29258535

Assuntos

Modelos Animais de Doenças; Linfo-Histiocitose Hemofagocítica/fisiopatologia; Linfo-Histiocitose Hemofagocítica/virologia; Muromegalovirus/fisiologia; Viroses/fisiopatologia; Replicação Viral/fisiologia; Animais; Antivirais/farmacologia; Cidofovir; Citosina/análogos & derivados; Citosina/farmacologia; Dexametasona/farmacologia; Humanos; Imunossupressores/farmacologia; Subunidade alfa de Receptor de Interleucina-2/efeitos dos fármacos; Subunidade alfa de Receptor de Interleucina-2/imunologia; Linfo-Histiocitose Hemofagocítica/tratamento farmacológico; Linfo-Histiocitose Hemofagocítica/imunologia; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Knockout; Organofosfonatos/farmacologia; Linfócitos T/efeitos dos fármacos; Linfócitos T/imunologia; Receptor 3 Toll-Like/agonistas; Receptor 3 Toll-Like/fisiologia; Receptor Toll-Like 9/agonistas; Receptor Toll-Like 9/fisiologia; Replicação Viral/efeitos dos fármacos

Palavras-chave

HLH; Hemophagocytic lymphohistiocytosis; MAS; MCMV; immunopathology; macrophage activation syndrome; mouse cytomegalovirus; mouse model; virus-mediated pathology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Replicação Viral / Viroses / Muromegalovirus / Modelos Animais de Doenças / Linfo-Histiocitose Hemofagocítica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Virol J Assunto da revista: VIROLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Bélgica

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