Maternal diabetes up-regulates NOX2 and enhances myocardial ischaemia/reperfusion injury in adult offspring.

Zhang, Lili; Wang, Xiaoyan; Wu, Yan; Lu, Xiangru; Chidiac, Peter; Wang, Guoping; Feng, Qingping

Zhang, Lili; Wang, Xiaoyan; Wu, Yan; Lu, Xiangru; Chidiac, Peter; Wang, Guoping; Feng, Qingping.

Afiliação

Zhang L; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang X; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Wu Y; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lu X; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Chidiac P; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Wang G; Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
Feng Q; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

J Cell Mol Med ; 22(4): 2200-2209, 2018 04.

Article em En | MEDLINE | ID: mdl-29377505

Assuntos

Envelhecimento/patologia; Diabetes Mellitus Experimental/patologia; Diabetes Gestacional/patologia; Traumatismo por Reperfusão Miocárdica/patologia; NADPH Oxidase 2/metabolismo; Regulação para Cima; Animais; Animais Recém-Nascidos; Apoptose; Células Cultivadas; Feminino; Glucose/toxicidade; Camundongos Endogâmicos C57BL; Miócitos Cardíacos/efeitos dos fármacos; Miócitos Cardíacos/metabolismo; Miócitos Cardíacos/patologia; Gravidez; Proteínas Proto-Oncogênicas c-akt/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

NOX2; developmental origins of health and disease; mTOR; maternal diabetes; myocardial ischaemia and reperfusion injury; reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Traumatismo por Reperfusão Miocárdica / Regulação para Cima / Diabetes Gestacional / Diabetes Mellitus Experimental / NADPH Oxidase 2 Limite: Animals / Pregnancy Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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