Structure-function analyses of a stereotypic rheumatoid factor unravel the structural basis for germline-encoded antibody autoreactivity.

Shiroishi, Mitsunori; Ito, Yuji; Shimokawa, Kenta; Lee, Jae Man; Kusakabe, Takahiro; Ueda, Tadashi

Shiroishi, Mitsunori; Ito, Yuji; Shimokawa, Kenta; Lee, Jae Man; Kusakabe, Takahiro; Ueda, Tadashi.

Afiliação

Shiroishi M; From the Laboratory of Protein Structure, Function, and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan and shiroish@phar.kyushu-u.ac.jp.
Ito Y; From the Laboratory of Protein Structure, Function, and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan and.
Shimokawa K; From the Laboratory of Protein Structure, Function, and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan and.
Lee JM; the Laboratory of Insect Genome Science, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Kusakabe T; the Laboratory of Insect Genome Science, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Ueda T; From the Laboratory of Protein Structure, Function, and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan and ueda@phar.kyushu-u.ac.jp.

J Biol Chem ; 293(18): 7008-7016, 2018 05 04.

Article em En | MEDLINE | ID: mdl-29523691

Assuntos

Autoanticorpos/química; Autoanticorpos/imunologia; Células Germinativas; Fator Reumatoide/metabolismo; Substituição de Aminoácidos; Afinidade de Anticorpos; Sítios de Ligação; Regiões Determinantes de Complementaridade; Cristalografia por Raios X; Epitopos/imunologia; Humanos; Interações Hidrofóbicas e Hidrofílicas; Imunoglobulina G/química; Imunoglobulina G/imunologia; Mutagênese; Conformação Proteica; Receptores Fc; Fator Reumatoide/química; Fator Reumatoide/imunologia; Relação Estrutura-Atividade

Palavras-chave

IgG; autoimmunity; complex; crystal structure; structural biology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Reumatoide / Autoanticorpos / Células Germinativas Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article

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