Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction.
Biomarkers
; 23(6): 540-550, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-29619838
ABSTRACT
OBJECTIVE:
Elevated levels of arginine derivatives in the NO pathway, such as asymmetric dimethylarginine (ADMA), are related to disease severity and reduced exercise capacity in heart failure (HF). We investigated the influence of exercise intervention on these parameters and on L-arginine (L-Arg) and L-homoarginine (L-hArg) in HF with preserved ejection fraction (HFpEF) patients. MATERIAL ANDMETHODS:
Sixty-two patients (65 ± 6 years) were included in this analysis and randomized to supervised endurance/resistance training (ET) or to usual care (UC). EDTA-plasma was analysed for NO metabolites.RESULTS:
There were baseline associations for adjusted values of maximum workload with ADMA (r= -0.322, p = 0.028) and L-Arg/ADMA ratio (r = 0.331, p = 0.015), and for the 6-min walk test (6MWT) with ADMA (r= -0.314, p = 0.024) and L-Arg/ADMA ratio (r = 0.346, p = 0.015). No significant differences between UC and ET changes of NO parameters were observed at 3-month follow-up. Higher L-hArg levels were associated with a greater improvement in peak oxygen uptake (peak [Formula see text]O2) at follow-up 3.4 ± 2.8 vs. 1.1 ± 2.9 mL/min/kg (p = 0.005).CONCLUSIONS:
Exercise intervention did not influence NO parameters in HFpEF patients, but L-hArg was related to change in peak [Formula see text]O2.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Volume Sistólico
/
Transdução de Sinais
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Terapia por Exercício
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Insuficiência Cardíaca
/
Óxido Nítrico
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biomarkers
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Alemanha