Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors.

Wang, Chenglin; Zhu, Mingfei; Lu, Xiuhong; Wang, Hong; Zhao, Weili; Zhang, Xiongwen; Dong, Xiaochun

Wang, Chenglin; Zhu, Mingfei; Lu, Xiuhong; Wang, Hong; Zhao, Weili; Zhang, Xiongwen; Dong, Xiaochun.

Afiliação

Wang C; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
Zhu M; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, PR China.
Lu X; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
Wang H; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, PR China.
Zhao W; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
Zhang X; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, PR China. Electronic address: xwzhang@sat.ecnu.edu.cn.
Dong X; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China. Electronic address: xcdong@fudan.edu.cn.

Bioorg Med Chem ; 26(12): 3308-3320, 2018 07 23.

Article em En | MEDLINE | ID: mdl-29739714

Assuntos

Antineoplásicos/síntese química; Proteínas Hedgehog/metabolismo; Piridazinas/química; Animais; Antineoplásicos/metabolismo; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Sítios de Ligação; Domínio Catalítico; Modelos Animais de Doenças; Desenho de Fármacos; Proteínas Hedgehog/antagonistas & inibidores; Meduloblastoma/tratamento farmacológico; Meduloblastoma/patologia; Camundongos; Camundongos Knockout; Camundongos Nus; Simulação de Acoplamento Molecular; Piridazinas/metabolismo; Piridazinas/farmacologia; Piridazinas/uso terapêutico; Transdução de Sinais/efeitos dos fármacos; Receptor Smoothened/química; Receptor Smoothened/metabolismo; Relação Estrutura-Atividade; Transplante Homólogo; Proteína Supressora de Tumor p53/deficiência; Proteína Supressora de Tumor p53/genética

Palavras-chave

Anti-tumor agents; Dimethylpyridazine; Hedgehog signaling pathway inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridazinas / Proteínas Hedgehog / Antineoplásicos Limite: Animals Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article

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