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Pulmonary Thermal Ablation Enables Long Chemotherapy-Free Survival in Metastatic Colorectal Cancer Patients.
Fonck, Mariane; Perez, Jean-Thomas; Catena, Vittorio; Becouarn, Yves; Cany, Laurent; Brudieux, Eric; Vayre, Laure; Texereau, Patrick; Le Brun-Ly, Valérie; Verger, Véronique; Brouste, Véronique; Bechade, Dominique; Buy, Xavier; Palussière, Jean.
Afiliação
  • Fonck M; Department of Medical Oncology, Institut Bergonié, 229 Cours de L'Argonne, 33000, Bordeaux, France.
  • Perez JT; Department of Interventional Radiology, Institut Bergonié, 229 Cours de L'Argonne, 33000, Bordeaux, France.
  • Catena V; Department of Interventional Radiology, Institut Bergonié, 229 Cours de L'Argonne, 33000, Bordeaux, France.
  • Becouarn Y; Department of Medical Oncology, Institut Bergonié, 229 Cours de L'Argonne, 33000, Bordeaux, France.
  • Cany L; Department of Oncology, Clinique Francheville, 38 Boulevard de Vésone, 24000, Périgueux, France.
  • Brudieux E; Department of Oncology, CH Pôle de Santé du Villeneuvois, Brignol Romas, 47305, Villeneuve-Sur-Lot, France.
  • Vayre L; Department of Oncology, CH Brive Bd Docteur Verlhac, 19100, Brive-La-Gaillarde, France.
  • Texereau P; Department of Oncology, Centre Hospitalier, Avenue Pierre de Coubertin BP 417, 40024, Mont-De-Marsan, France.
  • Le Brun-Ly V; Department of Oncology, CHU Limoges, 2 Avenue Martin Luther King, 87042, Limoges, France.
  • Verger V; Department of Oncology, CHI du pays de Cognac, 65 avenue d'Angoulême, 16112, Cognac, France.
  • Brouste V; Department of Clinical and Epidemiological Research, Institut Bergonié, 229 Cours de l'Argonne, 33000, Bordeaux, France.
  • Bechade D; Department of Medical Oncology, Institut Bergonié, 229 Cours de L'Argonne, 33000, Bordeaux, France.
  • Buy X; Department of Interventional Radiology, Institut Bergonié, 229 Cours de L'Argonne, 33000, Bordeaux, France.
  • Palussière J; Department of Interventional Radiology, Institut Bergonié, 229 Cours de L'Argonne, 33000, Bordeaux, France. j.palussiere@bordeaux.unicancer.fr.
Cardiovasc Intervent Radiol ; 41(11): 1727-1734, 2018 Nov.
Article em En | MEDLINE | ID: mdl-29766240
BACKGROUND: Chemotherapy (ct) is the preferred treatment option in metastatic colorectal cancer (mCRC). The objective of the study was to determine the overall survival (OS), disease-free survival (DFS) and ct-free survival (CFS) of pulmonary thermal ablation (TA) and its place in the treatment of mCRC. PATIENTS AND METHODS: All consecutive patients treated (over 11 years) with percutaneous TA for lung metastasis of colorectal origin were reviewed. All sequences of treatments were considered. We determined the OS, DFS and CFS of pulmonary TA. RESULTS: Two hundred and nine patients underwent 323 TA procedures for 630 lung metastases. Majority of the metastases (71.5%) were unilateral with a median diameter of 10 mm (2-46). A single metastasis was treated in 95 patients (45.5%), and 2-8 in 114 patients (54.5%). One hundred and thirty-two patients (63.2%) had only a single procedure, 77 patients (36.8%) had 2-5 procedures. Following the first TA (n = 209), 125 patients (59.8%) resumed ct. Sixty-four out of the 126 patients presenting lung progression were treated again with TA. The median CFS was 12.2 months (95% CI: 10.3-17.7). Patients with no extra-pulmonary metastases showed a statistically better CFS than those who had extra-pulmonary metastases with a median of 20.9 and 9.2 months, respectively (p < 0.001). Median follow-up and OS were 50 and 67.6 months, respectively. CONCLUSION: This study demonstrates, for the first time, that TA enables a CFS of 12.2 months that extended to 20.9 months in patients who presented with lung-only metastases. TA is a viable option for a pause in the therapy of mCRCs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Técnicas de Ablação / Neoplasias Pulmonares Limite: Aged / Female / Humans / Male Idioma: En Revista: Cardiovasc Intervent Radiol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Técnicas de Ablação / Neoplasias Pulmonares Limite: Aged / Female / Humans / Male Idioma: En Revista: Cardiovasc Intervent Radiol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França