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Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.
Yamasaki, Yuki; Kobayashi, Kaoru; Okuya, Fuka; Kajitani, Naoyo; Kazuki, Kanako; Abe, Satoshi; Takehara, Shoko; Ito, Shingo; Ogata, Seiryo; Uemura, Tatsuki; Ohtsuki, Sumio; Minegishi, Genki; Akita, Hidetaka; Chiba, Kan; Oshimura, Mitsuo; Kazuki, Yasuhiro.
Afiliação
  • Yamasaki Y; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Kobayashi K; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Okuya F; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Kajitani N; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Kazuki K; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Abe S; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Takehara S; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Ito S; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Ogata S; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Uemura T; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Ohtsuki S; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Minegishi G; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Akita H; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Chiba K; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Oshimura M; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
  • Kazuki Y; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of
Drug Metab Dispos ; 46(11): 1756-1766, 2018 11.
Article em En | MEDLINE | ID: mdl-29777024
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Preparações Farmacêuticas / Cromossomos / Membro 1 da Subfamília B de Cassetes de Ligação de ATP Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Preparações Farmacêuticas / Cromossomos / Membro 1 da Subfamília B de Cassetes de Ligação de ATP Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article