Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice.

Luo, Yu-Syuan; Furuya, Shinji; Soldatov, Valerie Y; Kosyk, Oksana; Yoo, Hong Sik; Fukushima, Hisataka; Lewis, Lauren; Iwata, Yasuhiro; Rusyn, Ivan

Luo, Yu-Syuan; Furuya, Shinji; Soldatov, Valerie Y; Kosyk, Oksana; Yoo, Hong Sik; Fukushima, Hisataka; Lewis, Lauren; Iwata, Yasuhiro; Rusyn, Ivan.

Afiliação

Luo YS; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas 77843.
Furuya S; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas 77843.
Soldatov VY; Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599.
Kosyk O; Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599.
Yoo HS; Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599.
Fukushima H; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas 77843.
Lewis L; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas 77843.
Iwata Y; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas 77843.
Rusyn I; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas 77843.

Toxicol Sci ; 164(2): 489-500, 2018 08 01.

Article em En | MEDLINE | ID: mdl-29897530

Assuntos

Citocromo P-450 CYP2E1/metabolismo; Família 2 do Citocromo P450/metabolismo; Tetracloroetileno/metabolismo; Tetracloroetileno/toxicidade; Tricloroetileno/metabolismo; Tricloroetileno/toxicidade; Animais; Citocromo P-450 CYP2E1/deficiência; Citocromo P-450 CYP2E1/genética; Família 2 do Citocromo P450/deficiência; Família 2 do Citocromo P450/genética; Feminino; Glutationa/metabolismo; Rim/efeitos dos fármacos; Rim/enzimologia; Rim/metabolismo; Fígado/efeitos dos fármacos; Fígado/enzimologia; Fígado/metabolismo; Masculino; Redes e Vias Metabólicas; Camundongos; Camundongos Knockout; Camundongos Transgênicos; Ácido Tricloroacético/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tetracloroetileno / Tricloroetileno / Citocromo P-450 CYP2E1 / Família 2 do Citocromo P450 Limite: Animals Idioma: En Revista: Toxicol Sci Assunto da revista: TOXICOLOGIA Ano de publicação: 2018 Tipo de documento: Article

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