Co-regulatory networks of human serum proteins link genetics to disease.
Science
; 361(6404): 769-773, 2018 08 24.
Article
em En
| MEDLINE
| ID: mdl-30072576
ABSTRACT
Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were measured in the serum of 5457 Icelanders over 65 years of age. Pairwise correlation between proteins as they varied across individuals revealed 27 different network modules of serum proteins, many of which were associated with cardiovascular and metabolic disease states, as well as overall survival. The protein modules were controlled by cis- and trans-acting genetic variants, which in many cases were also associated with complex disease. This revealed co-regulated groups of circulating proteins that incorporated regulatory control between tissues and demonstrated close relationships to past, current, and future disease states.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Sanguíneas
/
Doenças Cardiovasculares
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Proteoma
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Proteômica
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Doenças Metabólicas
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Science
Ano de publicação:
2018
Tipo de documento:
Article