Advancing the predictivity of skin sensitization by applying a novel HMOX1 reporter system.

Zhong, Guorui; Li, Haojian; Bai, Jing; Pang, Shihui; He, Changsheng; Du, Xinyi; Wang, Haijie; Zhang, Qixiao; Xie, Shuilin; Du, Hongli; Dai, Renke; Huang, Lizhen

Zhong, Guorui; Li, Haojian; Bai, Jing; Pang, Shihui; He, Changsheng; Du, Xinyi; Wang, Haijie; Zhang, Qixiao; Xie, Shuilin; Du, Hongli; Dai, Renke; Huang, Lizhen.

Afiliação

Zhong G; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
Li H; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
Bai J; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
Pang S; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
He C; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
Du X; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
Wang H; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
Zhang Q; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
Xie S; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
Du H; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
Dai R; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
Huang L; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China. huanglzh@scut.edu.cn.

Arch Toxicol ; 92(10): 3103-3115, 2018 10.

Article em En | MEDLINE | ID: mdl-30132045

Assuntos

Heme Oxigenase-1/genética; Queratinócitos/efeitos dos fármacos; Luciferases/genética; Testes de Irritação da Pele/métodos; Testes Cutâneos/métodos; Alternativas aos Testes com Animais; Sistemas CRISPR-Cas; Linhagem Celular; Genes Reporter; Células HEK293; Heme Oxigenase-1/metabolismo; Humanos; Queratinócitos/fisiologia; Luciferases/metabolismo; Sensibilidade e Especificidade

Palavras-chave

CRISPR/Cas9; Keratinocyte activation; Reporter cell line; Skin sensitization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes Cutâneos / Queratinócitos / Testes de Irritação da Pele / Heme Oxigenase-1 / Luciferases Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Arch Toxicol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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