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Combined diffusing capacity for nitric oxide and carbon monoxide as predictor of bronchiolitis obliterans syndrome following lung transplantation.
Winkler, Anna; Kahnert, Kathrin; Behr, Jürgen; Neurohr, Claus; Kneidinger, Nikolaus; Hatz, Rudolf; Dressel, Holger; Radtke, Thomas; Jörres, Rudolf A.
Afiliação
  • Winkler A; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Center Munich (CPC-M), Ludwig-Maximilians-Universität München, Munich, Germany.
  • Kahnert K; Department of Internal Medicine V, University of Munich (LMU), Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Ziemssenstr. 1, 80336, Munich, Germany. kathrin.kahnert@med.uni-muenchen.de.
  • Behr J; Department of Internal Medicine V, University of Munich (LMU), Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Ziemssenstr. 1, 80336, Munich, Germany.
  • Neurohr C; Robert-Bosch-Hospital, Klinik Schillerhöhe, Gerlingen, Germany.
  • Kneidinger N; Department of Internal Medicine V, University of Munich (LMU), Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Ziemssenstr. 1, 80336, Munich, Germany.
  • Hatz R; Department of Thoracic Surgery, University of Munich (LMU), Munich, Germany.
  • Dressel H; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
  • Radtke T; Division of Occupational and Environmental Medicine, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
  • Jörres RA; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Respir Res ; 19(1): 171, 2018 Sep 10.
Article em En | MEDLINE | ID: mdl-30200966
BACKGROUND: There is a need for non-invasive parameters that are sensitive to the development of the bronchiolitis obliterans syndrome (BOS) in lung transplantation (LTx) patients. We studied whether the pulmonary diffusing capacity for inhaled nitric oxide is capable of detecting BOS stages. METHODS: Sixty-one LTx patients were included into this cross-sectional study (19/29/7/3/3 in BOS stages 0/0-p/1/2/3). For analysis stages 0/0-p versus 1/2/3 ("BOS binary-early"), and stages 0/0-p/1 versus 2/3 ("BOS binary-late") were summarized. Measurements of the combined diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO) were compared with spirometry and bodyplethysmography, and their relative importance was evaluated by discriminant analysis. RESULTS: Regarding the recognition of "BOS binary-early", among spirometric parameters forced expiratory volume in 1 s (FEV1) was best, among bodyplethysmographic parameters airway resistance, and among diffusing parameters DLNO. Regarding "BOS binary-late", DLNO was inferior to bodyplethysmographic parameters. CONCLUSION: Although the study comprised only measurements at a single time point and no follow-up, DLNO outperformed FEV1, the time course of which is used in detecting BOS. Together with its pathophysiological plausibility, this result suggests that the measurement of DLNO, possibly over time, could be an easily applicable tool for the monitoring of LTx patients and should be evaluated in larger studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bronquiolite Obliterante / Monóxido de Carbono / Capacidade de Difusão Pulmonar / Transplante de Pulmão / Óxido Nítrico Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bronquiolite Obliterante / Monóxido de Carbono / Capacidade de Difusão Pulmonar / Transplante de Pulmão / Óxido Nítrico Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha