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Prevalence of hepatic steatosis as assessed by controlled attenuation parameter (CAP) in subjects with metabolic risk factors in primary care. A population-based study.
Fabrellas, Núria; Hernández, Rosario; Graupera, Isabel; Solà, Elsa; Ramos, Pilar; Martín, Natividad; Sáez, Gemma; Simón, Consuelo; Pérez, Almudena; Graell, Teresa; Larrañaga, Andrea; Garcia, Manel; de la Arada, Ana; Juanola, Adrià; Coiduras, Alicia; Duaso, Isabel; Casado, Angel; Martin, Julian; Ginès, Marta; Moreno, Nuria; Gema Perez, Ana; Marti, Laia; Bernat, Mireia; Sola, Montse; Olivé, Carmina; Solé, Cristina; Ginès, Pere.
Afiliação
  • Fabrellas N; School of Medicine and Health Sciences, University of Barcelona, Barcelona, Catalonia, Spain.
  • Hernández R; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
  • Graupera I; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Catalonia, Spain.
  • Solà E; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • Ramos P; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
  • Martín N; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Catalonia, Spain.
  • Sáez G; Liver Unit, Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain.
  • Simón C; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
  • Pérez A; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Catalonia, Spain.
  • Graell T; Liver Unit, Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain.
  • Larrañaga A; Liver Unit, Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain.
  • Garcia M; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • de la Arada A; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • Juanola A; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • Coiduras A; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • Duaso I; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • Casado A; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • Martin J; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • Ginès M; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • Moreno N; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
  • Gema Perez A; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Catalonia, Spain.
  • Marti L; Liver Unit, Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain.
  • Bernat M; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • Sola M; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • Olivé C; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • Solé C; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
  • Ginès P; Centre d'Assistència Primària La Marina, Institut Catalá de la Salut (ICS), Barcelona, Catalonia, Spain.
PLoS One ; 13(9): e0200656, 2018.
Article em En | MEDLINE | ID: mdl-30226889
ABSTRACT

BACKGROUND:

Primary care is the ideal setting for early identification of patients with non-alcoholic fatty liver disease (NAFLD). NAFLD is a potentially progressive disease that may lead to cirrhosis and liver cancer but is frequently underrecognized because subjects at risk are often not evaluated. Controlled attenuation parameter (CAP) is a reliable method for non-invasive quantification of liver fat. It has the advantage of simultaneous measurement of liver stiffness (LS), an estimate of liver fibrosis. There is no information on CAP in subjects with risk factors from primary care.

AIM:

To investigate the prevalence of hepatic steatosis, as estimated by CAP, in subjects from the community with metabolic risk factors and correlate findings with clinical and biochemical characteristics and LS. PATIENTS AND

METHODS:

Population-based study of 215 subjects with metabolic risk factors without known liver disease identified randomly from a primary care center. A control group of 80 subjects matched by age and sex without metabolic risk factors was also studied. CAP and LS were assessed using Fibroscan.

RESULTS:

Subjects with risk factors had CAP values higher than those of control group (268±64 vs 243±49dB/m,p<0.001). Prevalence of severe steatosis (CAP> 280dB/m) in subjects with risk factors was 43%. In multivariate analysis, fatty liver index (FLI) and HOMA were independent predictive factors of severe steatosis. There was a direct correlation between CAP and FLI values (r = 0.52,p<0.001). Interestingly, prevalence of increased LS was 12.6% in the risk group vs 0% in the control group (p<0.001). Increased LS occurred predominantly in subjects with high CAP values.

CONCLUSIONS:

A high proportion of subjects with metabolic risk factors seen in primary care have severe steatosis. FLI could be used as a surrogate of CAP. Increased LS was found in a significant proportion of subjects with risk factors but not in control subjects.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatopatia Gordurosa não Alcoólica / Doenças Metabólicas Tipo de estudo: Clinical_trials / Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatopatia Gordurosa não Alcoólica / Doenças Metabólicas Tipo de estudo: Clinical_trials / Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Espanha