Changes in Lesional and Non-lesional Skin Microbiome During Treatment of Atopic Dermatitis.
Acta Derm Venereol
; 99(3): 284-290, 2019 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-30460369
ABSTRACT
The aim of this study was to evaluate changes in the skin surface microbiome in patients with atopic dermatitis during treatment. The effect of narrowband ultraviolet B phototherapy was also studied to determine the influence of exposure to ultraviolet. A total of 18 patients with atopic dermatitis were included in the study. Patients were divided into 2 groups based on treatment 1 group treated with narrowband ultraviolet B phototherapy and topical corticosteroid, and the other group treated with topical corticosteroid only. Skin swabs and high-throughput sequencing of 16S ribosomal RNA bacterial genes were performed at 3 time-points. The microbial diversity of lesional skin increased greatly after treatment. The proportion of Staphylococcus aureus showed a significant positive correlation with eczema severity. In conclusion, a drastic increase in microbial diversity and decrease in S. aureus proportion were observed with eczema treatment. Narrowband ultraviolet B treatment did not exert additive effects on eczema improvement; however, it appeared to reduce the recurrence of eczema.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
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Staphylococcus aureus
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Terapia Ultravioleta
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Corticosteroides
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Dermatite Atópica
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Microbiota
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Acta Derm Venereol
Ano de publicação:
2019
Tipo de documento:
Article