YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer - Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer.

Li, Fan; Xu, Yan; Liu, Bovey; Singh, Pankaj Kumar; Zhao, Wei; Jin, Jiankang; Han, Guangchun; Scott, Ailing W; Dong, Xiaochuan; Huo, Longfei; Ma, Lang; Pizzi, Melissa Pool; Wang, Ying; Li, Yuan; Harada, Kazuto; Xie, Min; Skinner, Heath D; Ding, Sheng; Wang, Linghua; Krishnan, Sunil; Johnson, Randy L; Song, Shumei; Ajani, Jaffer A

Li, Fan; Xu, Yan; Liu, Bovey; Singh, Pankaj Kumar; Zhao, Wei; Jin, Jiankang; Han, Guangchun; Scott, Ailing W; Dong, Xiaochuan; Huo, Longfei; Ma, Lang; Pizzi, Melissa Pool; Wang, Ying; Li, Yuan; Harada, Kazuto; Xie, Min; Skinner, Heath D; Ding, Sheng; Wang, Linghua; Krishnan, Sunil; Johnson, Randy L; Song, Shumei; Ajani, Jaffer A.

Afiliação

Li F; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Xu Y; Department of General Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
Liu B; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Singh PK; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Zhao W; Department of Radiation Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Jin J; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Han G; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Scott AW; Department of Genomic Medicine, U.T.MD. Anderson Cancer Center, Houston, Texas.
Dong X; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Huo L; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Ma L; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Pizzi MP; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Wang Y; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Li Y; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Harada K; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Xie M; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Skinner HD; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California.
Ding S; Department of Radiation Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Wang L; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California.
Krishnan S; Department of Genomic Medicine, U.T.MD. Anderson Cancer Center, Houston, Texas.
Johnson RL; Department of Radiation Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Song S; Department of Cancer Biology, U.T.MD. Anderson Cancer Center, Houston, Texas.
Ajani JA; Department of Gastrointestinal Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, Texas. ssong@mdanderson.org jajani@mdanderson.org.

Clin Cancer Res ; 25(7): 2264-2277, 2019 04 01.

Article em En | MEDLINE | ID: mdl-30563933

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Quinase 6 Dependente de Ciclina/metabolismo; Neoplasias Esofágicas/metabolismo; Tolerância a Radiação; Fatores de Transcrição/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/genética; Animais; Ciclo Celular/efeitos dos fármacos; Ciclo Celular/genética; Linhagem Celular Tumoral; Terapia Combinada; Quinase 6 Dependente de Ciclina/genética; Modelos Animais de Doenças; Resistencia a Medicamentos Antineoplásicos/genética; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/patologia; Neoplasias Esofágicas/terapia; Expressão Gênica; Técnicas de Inativação de Genes; Genes Reporter; Humanos; Imuno-Histoquímica; Camundongos; Modelos Biológicos; Células-Tronco Neoplásicas/efeitos dos fármacos; Células-Tronco Neoplásicas/metabolismo; Ligação Proteica; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/uso terapêutico; Tolerância a Radiação/genética; Fatores de Transcrição/genética; Ensaios Antitumorais Modelo de Xenoenxerto; Proteínas de Sinalização YAP

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tolerância a Radiação / Fatores de Transcrição / Neoplasias Esofágicas / Proteínas Adaptadoras de Transdução de Sinal / Quinase 6 Dependente de Ciclina Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article

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