Management of hypothalamic disease in patients with craniopharyngioma.
Clin Endocrinol (Oxf)
; 90(4): 506-516, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30614015
ABSTRACT
Patients with craniopharyngioma experience excess morbidity and mortality when compared with the background population and with other hypopituitary patients. Large, suprasellar tumours which form micropapillae into surrounding structures can cause hypothalamic damage before any therapeutic intervention; attempted gross total resection can lead to hypothalamic obesity, sleep disorders, thirst disorders and dysregulation of temperature as well as panhypopituitarism. The management of tumour bulk and the pathophysiology of hypothalamic complications have been reviewed extensively. We present a practical, clinical approach to management of hypothalamic disease in a patient with craniopharyngioma and highlight potential targets for future pharmacological or surgical intervention.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Craniofaringioma
/
Doenças Hipotalâmicas
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Endocrinol (Oxf)
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Irlanda