Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units.

Kalkreuter, Edward; CroweTipton, Jared M; Lowell, Andrew N; Sherman, David H; Williams, Gavin J

Kalkreuter, Edward; CroweTipton, Jared M; Lowell, Andrew N; Sherman, David H; Williams, Gavin J.

Afiliação

Kalkreuter E; Department of Chemistry , NC State University , Raleigh , North Carolina 27695 , United States.
CroweTipton JM; Comparative Medicine Institute , NC State University , Raleigh , North Carolina 27695 , United States.
Lowell AN; Department of Chemistry , NC State University , Raleigh , North Carolina 27695 , United States.
Sherman DH; Life Sciences Institute, Department of Medicinal Chemistry , University of Michigan , Ann Arbor , Michigan 48109 , United States.
Williams GJ; Life Sciences Institute, Department of Medicinal Chemistry , University of Michigan , Ann Arbor , Michigan 48109 , United States.

J Am Chem Soc ; 141(5): 1961-1969, 2019 02 06.

Article em En | MEDLINE | ID: mdl-30676722

Assuntos

Policetídeo Sintases/química; Engenharia de Proteínas; Estrutura Molecular; Policetídeo Sintases/metabolismo; Especificidade por Substrato

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Policetídeo Sintases Idioma: En Revista: J Am Chem Soc Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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