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BMP signaling is required for amphioxus tail regeneration.
Liang, Yujun; Rathnayake, Delima; Huang, Shibo; Pathirana, Anjalika; Xu, Qiyu; Zhang, Shicui.
Afiliação
  • Liang Y; Department of Marine Biology, Institute of Evolution and Marine Biodiversity and College of Marine Life Science, Ocean University of China, Qingdao 266003, China liangyujun@ouc.edu.cn sczhang@ouc.edu.cn.
  • Rathnayake D; Department of Marine Biology, Institute of Evolution and Marine Biodiversity and College of Marine Life Science, Ocean University of China, Qingdao 266003, China.
  • Huang S; Department of Marine Biology, Institute of Evolution and Marine Biodiversity and College of Marine Life Science, Ocean University of China, Qingdao 266003, China.
  • Pathirana A; Department of Marine Biology, Institute of Evolution and Marine Biodiversity and College of Marine Life Science, Ocean University of China, Qingdao 266003, China.
  • Xu Q; Department of Marine Biology, Institute of Evolution and Marine Biodiversity and College of Marine Life Science, Ocean University of China, Qingdao 266003, China.
  • Zhang S; Department of Marine Biology, Institute of Evolution and Marine Biodiversity and College of Marine Life Science, Ocean University of China, Qingdao 266003, China liangyujun@ouc.edu.cn sczhang@ouc.edu.cn.
Development ; 146(4)2019 02 15.
Article em En | MEDLINE | ID: mdl-30696711
ABSTRACT
Amphioxus, a cephalochordate, is an ideal animal in which to address questions about the evolution of regenerative ability and the mechanisms behind the invertebrate to vertebrate transition in chordates. However, the cellular and molecular basis of tail regeneration in amphioxus remains largely ill-defined. We confirmed that the tail regeneration of amphioxus Branchiostoma japonicum is a vertebrate-like epimorphosis process. We performed transcriptome analysis of tail regenerates, which provided many clues for exploring the mechanism of tail regeneration. Importantly, we showed that BMP2/4 and its related signaling pathway components are essential for the process of tail regeneration, revealing an evolutionarily conserved genetic regulatory system involved in regeneration in many metazoans. We serendipitously discovered that bmp2/4 expression is immediately inducible by general wounds and that expression of bmp2/4 can be regarded as a biomarker of wounds in amphioxus. Collectively, our results provide a framework for understanding the evolution and diversity of cellular and molecular events of tail regeneration in vertebrates.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Cauda / Transdução de Sinais / Proteína Morfogenética Óssea 2 / Proteína Morfogenética Óssea 4 / Anfioxos Limite: Animals Idioma: En Revista: Development Assunto da revista: BIOLOGIA / EMBRIOLOGIA Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Cauda / Transdução de Sinais / Proteína Morfogenética Óssea 2 / Proteína Morfogenética Óssea 4 / Anfioxos Limite: Animals Idioma: En Revista: Development Assunto da revista: BIOLOGIA / EMBRIOLOGIA Ano de publicação: 2019 Tipo de documento: Article