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Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1ß secretion by bronchoalveolar fluid macrophages from asthmatic subjects.
Gordon, Elizabeth M; Yao, Xianglan; Xu, Haitao; Karkowsky, William; Kaler, Maryann; Kalchiem-Dekel, Or; Barochia, Amisha V; Gao, Meixia; Keeran, Karen J; Jeffries, Kenneth R; Levine, Stewart J.
Afiliação
  • Gordon EM; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
  • Yao X; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
  • Xu H; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
  • Karkowsky W; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
  • Kaler M; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
  • Kalchiem-Dekel O; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
  • Barochia AV; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
  • Gao M; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
  • Keeran KJ; Animal Surgery and Resources Core Facility, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
  • Jeffries KR; Animal Surgery and Resources Core Facility, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
  • Levine SJ; Laboratory of Asthma and Lung Inflammation, Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. Electronic address: levines@nhlbi.nih.gov.
J Allergy Clin Immunol ; 144(2): 426-441.e3, 2019 08.
Article em En | MEDLINE | ID: mdl-30872118
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Asma / Líquido da Lavagem Broncoalveolar / Transdução de Sinais / Interleucina-1beta / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Macrófagos Limite: Animals / Female / Humans / Male Idioma: En Revista: J Allergy Clin Immunol Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Asma / Líquido da Lavagem Broncoalveolar / Transdução de Sinais / Interleucina-1beta / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Macrófagos Limite: Animals / Female / Humans / Male Idioma: En Revista: J Allergy Clin Immunol Ano de publicação: 2019 Tipo de documento: Article