4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of <i>Apoe<sup>-/-</sup></i> mice.

Lynn, Edward G; Lhoták, Sárka; Lebeau, Paul; Byun, Jae Hyun; Chen, Jack; Platko, Khrystyna; Shi, Chunhua; O'Brien, Edward R; Austin, Richard C

4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe^-/- mice.

Lynn, Edward G; Lhoták, Sárka; Lebeau, Paul; Byun, Jae Hyun; Chen, Jack; Platko, Khrystyna; Shi, Chunhua; O'Brien, Edward R; Austin, Richard C.

Afiliação

Lynn EG; Division of Nephrology, Department of Medicine, McMaster University-The Research Institute of St. Joe's Hamilton-Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada; and.
Lhoták S; Division of Nephrology, Department of Medicine, McMaster University-The Research Institute of St. Joe's Hamilton-Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada; and.
Lebeau P; Division of Nephrology, Department of Medicine, McMaster University-The Research Institute of St. Joe's Hamilton-Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada; and.
Byun JH; Division of Nephrology, Department of Medicine, McMaster University-The Research Institute of St. Joe's Hamilton-Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada; and.
Chen J; Division of Nephrology, Department of Medicine, McMaster University-The Research Institute of St. Joe's Hamilton-Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada; and.
Platko K; Division of Nephrology, Department of Medicine, McMaster University-The Research Institute of St. Joe's Hamilton-Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada; and.
Shi C; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
O'Brien ER; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Austin RC; Division of Nephrology, Department of Medicine, McMaster University-The Research Institute of St. Joe's Hamilton-Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada; and.

FASEB J ; 33(7): 8406-8422, 2019 07.

Article em En | MEDLINE | ID: mdl-30964709

Assuntos

Aterosclerose/prevenção & controle; Diferenciação Celular/efeitos dos fármacos; Proteínas de Choque Térmico/biossíntese; Macrófagos/metabolismo; Chaperonas Moleculares/biossíntese; Monócitos/metabolismo; Fenilbutiratos/farmacologia; Animais; Aterosclerose/genética; Aterosclerose/metabolismo; Aterosclerose/patologia; Adesão Celular/efeitos dos fármacos; Adesão Celular/genética; Morte Celular/efeitos dos fármacos; Morte Celular/genética; Diferenciação Celular/genética; Proteínas de Choque Térmico/genética; Humanos; Macrófagos/patologia; Camundongos; Camundongos Knockout para ApoE; Chaperonas Moleculares/genética; Monócitos/patologia; Células THP-1

Palavras-chave

atherosclerosis; chaperones; mouse; small HSP

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilbutiratos / Monócitos / Diferenciação Celular / Chaperonas Moleculares / Aterosclerose / Proteínas de Choque Térmico / Macrófagos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2019 Tipo de documento: Article

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