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Discovery of selective activators of PRC2 mutant EED-I363M.
Suh, Junghyun L; Barnash, Kimberly D; Abramyan, Tigran M; Li, Fengling; The, Juliana; Engelberg, Isabelle A; Vedadi, Masoud; Brown, Peter J; Kireev, Dmitri B; Arrowsmith, Cheryl H; James, Lindsey I; Frye, Stephen V.
Afiliação
  • Suh JL; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
  • Barnash KD; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
  • Abramyan TM; Foghorn Therapeutics, Cambridge, MA, 02142, USA.
  • Li F; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
  • The J; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, M5G 1L7, Canada.
  • Engelberg IA; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, M5G 1L7, Canada.
  • Vedadi M; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
  • Brown PJ; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, M5G 1L7, Canada.
  • Kireev DB; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, M5G 1L7, Canada.
  • Arrowsmith CH; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
  • James LI; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, M5G 1L7, Canada. Cheryl.Arrowsmith@uhnresearch.ca.
  • Frye SV; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada. Cheryl.Arrowsmith@uhnresearch.ca.
Sci Rep ; 9(1): 6524, 2019 04 25.
Article em En | MEDLINE | ID: mdl-31024026
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Complexo Repressor Polycomb 2 / Mutação Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Complexo Repressor Polycomb 2 / Mutação Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos