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Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
El Bakkouri, Majida; Kouidmi, Imène; Wernimont, Amy K; Amani, Mehrnaz; Hutchinson, Ashley; Loppnau, Peter; Kim, Jeong Joo; Flueck, Christian; Walker, John R; Seitova, Alma; Senisterra, Guillermo; Kakihara, Yoshito; Kim, Choel; Blackman, Michael J; Calmettes, Charles; Baker, David A; Hui, Raymond.
Afiliação
  • El Bakkouri M; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Kouidmi I; INRS-Institut Armand-Frappier, Laval, QC H7V 1B7, Canada.
  • Wernimont AK; INRS-Institut Armand-Frappier, Laval, QC H7V 1B7, Canada.
  • Amani M; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Hutchinson A; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Loppnau P; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Kim JJ; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Flueck C; Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030.
  • Walker JR; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, United Kingdom.
  • Seitova A; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Senisterra G; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Kakihara Y; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Kim C; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A1, Canada.
  • Blackman MJ; Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030.
  • Calmettes C; Verna and Marss McLean Department of Biochemistry and Molecular Biology, Baylor School of Medicine, Houston, TX 77030.
  • Baker DA; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, United Kingdom.
  • Hui R; Malaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Proc Natl Acad Sci U S A ; 116(28): 14164-14173, 2019 07 09.
Article em En | MEDLINE | ID: mdl-31239348
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Conformação Proteica / Proteínas Quinases Dependentes de GMP Cíclico / Malária Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Conformação Proteica / Proteínas Quinases Dependentes de GMP Cíclico / Malária Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá