Engineering Metalloprotein Functions in Designed and Native Scaffolds.
Trends Biochem Sci
; 44(12): 1022-1040, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31307903
ABSTRACT
Metalloproteins are crucial for life. The mutual relationship between metal ions and proteins makes metalloproteins able to accomplish key processes in biological systems, often very difficult to reproduce with inorganic coordination compounds under mild conditions. Taking inspiration from nature, many efforts have been devoted to developing artificial molecules as metalloprotein mimics. We have witnessed an explosion of protein design strategies leading to designed metalloproteins, ranging from stable structures to functional molecules. This review illustrates the most recent results for inserting metalloprotein functions in designed and engineered protein scaffolds. The selected examples highlight the potential of different approaches for the construction of artificial molecules capable of simulating and even overcoming the features of natural metalloproteins.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Engenharia de Proteínas
/
Metaloproteínas
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Itália